GLP-1/GIP dual agonist
C225H348N48O68
- Molar mass
- 4,813 g/mol
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PeptidesIn stock
TZ5 10mg
GLP-1/GIP dual agonist · 1 vial
$108.00CAD$10.80 per mg
Buy TZ5 10mg online in Canada. High-purity research peptide for effective fat loss, glycemic control, and sustained appetite reduction. Order from SteroidsCanada.is – 98%+ HPLC-tested purity, discreet packaging, and fast Canadian delivery.
Free shipping on orders over $300 CAD. Add $192 more with this item to qualify.
Needed with this: Bacteriostatic waterPowder vials are mixed with bacteriostatic water before use. $60AddDelivery guaranteed: lost or seized, we reship your order free. Delivery policy
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You will need
EasyTouch Insulin Syringes 30G U-100 (bag of 10)$15 · 1 ml U-100 barrels for under-the-skin dosesAddIt ships by Canada Post Xpresspost with tracking.
- Ships from inside Canada
- Plain, unbranded box
- Pay by Interac e-Transfer
- Lost or seized: reshipped free
Spec sheetGLP-1/GIP dual agonistTZ5-10MG-V2
- Compound
- GLP-1/GIP dual agonist
- Strength
- 10 mg per vial
- Pack
- 1 vial
- Total per order
- 10 mg
- Form
- Lyophilized powder (vial)
- Half-life
- About 5 days
- Value
- $10.80 per mg
01The basics
What TZ5 10mg is
TZ5 is a once-weekly injectable peptide that improves blood sugar control and supports weight loss. Each vial contains 10 mg of freeze-dried powder for mixing with bacteriostatic water. It’s a dual agonist: it acts on both GLP-1 and GIP receptors, two gut hormones that control appetite and insulin.
In major clinical trials, this compound produced some of the largest weight losses of any approved medicine. It’s also a serious drug: most people get stomach side effects at first, and there are rare but important risks. Because you mix and measure it yourself, the math below matters.
02Molecule
The molecule
What is actually in the vial or tablet, from the public chemistry databases of the U.S. National Library of Medicine.
03How it works
How it works
- GLP-1 action: slows stomach emptying, increases fullness and boosts insulin when blood sugar is high.
- GIP action: adds to the insulin and appetite effects, and may improve how the body handles fat.
- Once a week: a half-life of about 5 days.
04Half-life
Half-life, in plain numbers
A half-life of about 5 days means half of what is in the body is gone after that time, then half of the rest, and so on. For an injected peptide it reflects how quickly the body breaks the chain down and clears it.
- One half-life
- 5 days
- About 97% gone
- 25 days
- Levels level out with regular use after
- 20 days–25 days
A textbook model built from the half-life alone. Real numbers vary from person to person.
05Clinical reference
Dosing information
Clinical reference. The labeled schedule starts at 2.5 mg once a week for 4 weeks, then increases by 2.5 mg every 4 weeks as tolerated, to a maintenance dose of 5, 10 or 15 mg a week (maximum 15 mg). In the SURMOUNT-1 trial, 15 mg a week produced an average weight loss of about 21% over 72 weeks.
Talk to a doctor before use.
Mixing math. Adding 2 ml of bacteriostatic water to the 10 mg vial gives 5 mg per ml. On a U-100 insulin syringe:
- 2.5 mg = 0.5 ml = 50 units
- 5 mg = 1 ml = 100 units
The vial holds four 2.5 mg doses or two 5 mg doses. Write the concentration on the vial.
06Measure it
Measure it
Type in the amount your prescriber gave you, or the one you are working from, and this turns it into what to draw up or count out from this exact product. It only does the arithmetic; it never suggests an amount.
Result
—
Enter your amount
- —
- —
Arithmetic from the strength printed on this product. Always check your own vial or bottle, follow your prescriber, and ask a pharmacist to show you how to measure if you are unsure.
07Injection sites
Where it is injected
TZ5 10mg arrives as a freeze-dried powder. After it is mixed with bacteriostatic water it is normally injected under the skin, into the fat layer, with a short insulin needle.
1Belly (abdomen)Fat under the skin of the bellySubQ
Volume per siteAbout 1 ml or lessNeedle4–13 mm insulin needle, 29–31G
- Pick a spot at least 5 cm (two finger-widths) from the belly button.
- Avoid scars, stretch marks, bruises and the waistband.
- Pinch up a fold of skin and inject into the fold.
Why it is used. The most fat to work with, easy to see, and the steadiest absorption. Weekly pen medicines list it first.
Careful. Move each injection at least 2–3 cm from the last to avoid firm fatty lumps (lipohypertrophy).
Belly injections: distance from the navelMassachusetts General Hospital, Patient educationSection 0:00–0:44 of their video · YouTube
2Front of thighFat under the skin of the thighSubQ
Volume per siteAbout 1 ml or lessNeedle4–13 mm insulin needle, 29–31G
- Sit and look down at the front of your thigh.
- Use the middle band: a hand-width below the hip crease and a hand-width above the knee.
- Pinch the skin and inject into the fold.
Why it is used. Easy to reach while seated, and a handy second area to rotate with the belly.
Careful. It can absorb a little more slowly than the belly; hard leg training straight afterwards can speed it up.
Thigh injections: where the safe band isMassachusetts General Hospital, Patient educationSection 0:43–1:06 of their video · YouTube
3Back of upper armFat over the tricepsSubQ
Volume per siteAbout 1 ml or lessNeedle4–13 mm insulin needle, 29–31G
- Find the soft, fleshy area at the back of the upper arm.
- Stay halfway between the shoulder and the elbow.
- Pinch the skin and inject into the fold.
Why it is used. A third area to rotate through, so every spot gets a longer rest.
Careful. Hard to pinch and reach with one hand; most people need a helper.
Back of the arm and moving between spotsMassachusetts General Hospital, Patient educationSection 1:05–1:46 of their video · YouTube
Route for TZ5 10mgUnder the skin (subQ)
- Same areas as the weekly pensWeekly injectables in this class are labelled for the belly, thigh or back of the arm. Choose an area and move to a fresh spot each week.
- Start with the bellyIt has the most fat and the steadiest absorption, and you can see what you are doing. The thigh and arm are there to rotate into.
- Short needle, small volumeAround 1 ml or less per spot. A 4–13 mm insulin needle reaches the fat without touching muscle; pinch up the skin if you are lean.
- New spot every timeShift 2–3 cm from the last injection. Reusing one spot causes firm lumps that absorb unevenly.
- Wash your hands
- Alcohol on the stopper and skin, let it dry
- New sterile needle and syringe every time
- Never share any of it
- Sharps into a puncture-proof container
General reference from standard nursing injection guidance, not medical advice. Spreading redness, heat, swelling, pus, fever, numbness or pain that keeps getting worse needs a doctor. A pharmacist or nurse can show you the technique in person.
08Brand vs brand
Brand vs brand
The same compound from another maker. What changes is the pack, the strength per tablet or ml, and the price per unit.
TZ5 10mg
- Strength
- 10 mg per vial
- Pack
- 1 vial
- Total
- 10 mg
- Per unit
- $10.80 per mg
- Rating
- No reviews yet
$108.00
TZ-2 10mg
- Strength
- 10 mg per vial
- Pack
- 1 vial
- Total
- 10 mg
- Per unit
- $13.20 per mg
- Rating
- No reviews yet
$132.00
Add to cart
TZ-2 5mg
- Strength
- 5 mg per vial
- Pack
- 1 vial
- Total
- 5 mg
- Per unit
- $22.80 per mg
- Rating
- No reviews yet
$114.00
Add to cart09Risks
Side effects and risks
Stomach side effects are common and tend to ease. The rest are less common but serious.
Nausea and digestion
Nausea, vomiting, diarrhea and constipation, worst after starting or raising the dose. Severe vomiting can dehydrate you and harm your kidneys.
Pancreatitis
Severe, persistent stomach pain that may spread to the back: stop and go to an emergency department.
Gallbladder
Gallstones are more likely with fast weight loss. Upper-right pain, fever or yellow skin need a doctor.
Thyroid warning
This compound caused thyroid C-cell tumours in rats; whether it does in humans is unknown. Report a neck lump, hoarseness or trouble swallowing.
Low blood sugar
Mainly when combined with insulin or sulfonylureas.
Don’t use it if you
Or a family member have had medullary thyroid cancer or MEN 2, you’ve had pancreatitis, you have type 1 diabetes, you’re pregnant, breastfeeding or planning pregnancy, or you’re under 18.
10Interactions
Interactions
Medicines and substances that change how this product behaves, or that it changes. Show this list to your pharmacist along with everything else you take.
- SeriousInsulin and sulfonylureas
Gliclazide, glyburide and insulin together with a GLP-1 medicine cause low blood sugar more often; doctors usually lower those doses first.
- CautionTablets that need steady levels
Stomach emptying slows, which can change how warfarin, levothyroxine and other narrow-range tablets are absorbed. INR or thyroid levels may need an extra check.
- CautionA second GLP-1 medicine
Never use two drugs from this class at the same time (semaglutide, liraglutide, dulaglutide, TZ5, Reta).
- Good to knowAlcohol
Adds to the risk of low blood sugar and of pancreatitis.
- CautionBirth control pills
For this dual agonist the label warns pills can be less reliable for 4 weeks after starting and after each dose increase; a barrier method covers that gap.
11Bloodwork
Bloodwork checklist
Test before you start and about every 3 months.
- A1C and fasting glucose
- Kidney function
- Liver panel and lipids
- At home: weight and blood pressure
12Support
Getting the most from it
- Eat protein at every meal and lift weights to protect muscle.
- Eat smaller meals and stop at the first sign of fullness.
- Stay hydrated and eat fibre to manage constipation.
- Keep the mixed vial in the fridge (2–8 °C); never freeze it.
- Tell your surgeon or anesthetist before any procedure.
13Pairs well with
Pairs well with
14Delivery
Delivery across Canada
Everything ships from inside Canada, so there is no border, no customs and no currency conversion.
Canada Post Xpresspost$30Free on orders over $300
Purolator / FedEx$60Courier option at checkout
- DispatchOrders ship by Canada Post Xpresspost, with tracking within 72 hours of payment. Customers commonly report 2 to 4 days to arrive, depending on the province and postal code.
- PackagingA plain outer box with no product names or branding.
- Delivery guaranteeIf a parcel is lost or seized in transit, we reship it free. Delivery policy
- ReturnsBecause of what these products are, opened or delivered orders can’t be returned. A wrong item is replaced free.
- PaymentInterac e-Transfer, priced in Canadian dollars.
15Questions
Common questions
TZ5 or semaglutide (SM5)?
Both are weekly injections. TZ5 also acts on GIP, and in a head-to-head trial it produced more weight loss on average than semaglutide.
How does the 10 mg vial compare to the 5 mg vial?
Same compound; the 10 mg vial simply holds twice as much and suits higher doses. Compare them under Compare brands on this page.
Is TZ-2 the same as TZ5?
Yes. They’re different listings of the same compound.
How fast is shipping in Canada?
Orders ship by Canada Post Xpresspost, with tracking within 72 hours of payment, with tracking.
Is TZ5 legal in Canada?
Its active compound is a prescription drug in Canada. It isn’t a controlled substance.
How is my order packaged?
In a plain, unbranded box with no product names on the outside.
16Research
Research behind this page
The studies and guidelines the clinical and safety information above leans on. Every link opens the record on PubMed.
- 1Once-weekly GLP-1/GIP dual agonist for the treatment of obesity (SURMOUNT-1 trial)
N Engl J Med2022Jastreboff AM et al.PMID 35658024
- 2GLP-1/GIP dual agonist versus semaglutide once weekly in type 2 diabetes (SURPASS-2 trial)
N Engl J Med2021Frías JP et al.PMID 34170647
17Reviews
What customers say
No reviews for this product yet. After an order is delivered we email the customer a link to review it.
Educational information only, not medical advice. Talk to a doctor or pharmacist before using any anabolic steroid, hormone, peptide or prescription drug. Adults 18+ only. Sold and shipped from Canada by SteroidsCanada.is.